This profile measures 7 key hormones in saliva using the highly precise LC-MS method, available for both females and males: (S-125)
Why it matters: LC-MS provides a detailed view of the full steroid hormone cascade, offering deeper insight into clinical issues that may arise from insufficient or excessive hormone therapies.
ZRT Laboratory now offers a comprehensive LC-MS/MS saliva assay that measures the levels of 7 endogenous steroid hormones, including estrogens, progestogens, and androgens. The LC-MS/MS assay expands beyond the 5-steroid panel of parent hormones (estradiol, progesterone, testosterone, DHEAS, and cortisol) currently tested by immunoassay (IA) at ZRT Laboratory.
LC-MS has some advantages over EIA and vice versa. LC-MS is more sensitive at very low levels, which can be helpful when hormones are in very low concentrations. LC-MS may also offer advantages when high-dose hormones are being used topically, which may cause cross-reactions with antibody testing.
It is also a great test to determine how different types of hormones and their administration routes (e.g., oral, topical, transdermal patch, IM/SC injections, pellet, vaginal) affect their bioavailable (saliva) levels.
The LC-MS test is also a more useful tool for understanding what pathways precursor hormone therapies (e.g., pregnenolone, DHEA, progesterone, and testosterone) take to become active estrogens, progestogens, and androgens.
All Tests Included:
Estrogens: Estradiol (E2), Estriol (E3), Estrone (E1), Progesterone (Pg), Testosterone (T), DHEA-S (DS), and Cortisol (C).
| Lab | |
|---|---|
| ZRT | |
| Sample Type | |
| Saliva | |
| Estrogens (LCMS-Saliva) | |
| Estradiol (E2) | |
| Estriol (E3) | |
| Estrone (E1) | |
| Progestogens (LCMS-Saliva) | |
| Progesterone (Pg) | |
| Androgens (LCMS-Saliva) | |
| Testosterone (T) | |
| Adrenal (LCMS-Saliva) | |
| Dehydroepiandrosterone sulfate (DHEA-S), (DS) | |
| Glucocorticoids (LCMS-Saliva) | |
| Free Cortisol (FCnx1) (C) | |
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